Caffeine as A Catalyst for A Four-Component Synthesis of Dihydropyrano [2, 3-C]Pyrazoles in Water

  • Mohammad Bakherad Shahrood University of Technology
  • Amir H Amin Shahrood University of Technology
  • Rahele Doosti Shahrood University of Technology
Keywords: Four-component reaction, Caffeine, Pyrano[2,3-c]pyrazole, Green Catalyst, Aldehyde

Abstract

We describe a one-pot four component synthesis of pyrano[2,3-c]pyrazoles from hydrazine hydrate or phenyl hydrazine, ethyl acetoacetate, an aldehyde, and malononitrile in the presence of catalytic amounts of a caffeine as a green catalyst in water at 50 ºC. The present protocol offers the advantages of a clean reaction, a short reaction time, a high product yield, and an environmentally-friendly, easily-purified, and economically-available catalyst.

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Author Biographies

Mohammad Bakherad, Shahrood University of Technology

Faculty of Chemistry, Shahrood University of Technology, Shahrood, 3619995161, Iran

Amir H Amin, Shahrood University of Technology

Faculty of Chemistry, Shahrood University of Technology, Shahrood, 3619995161, Iran

Rahele Doosti, Shahrood University of Technology

Faculty of Chemistry, Shahrood University of Technology, Shahrood, 3619995161, Iran

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Published
2019-04-17
How to Cite
Bakherad, M., Amin, A. H., & Doosti, R. (2019). Caffeine as A Catalyst for A Four-Component Synthesis of Dihydropyrano [2, 3-C]Pyrazoles in Water. To Chemistry Journal, 2, 154-164. Retrieved from http://purkh.com/index.php/tochem/article/view/372
Section
Research Articles