Oxidative Cleavage of Solbutamol by N- Chloro Saccharin in Aqueous Acetic Acid Medium

Keywords: 3-hydroxy methyl, AcOH|, N-Chlorosacharin, 4-hydroxy benzene carbaldehyde Perchloric acid, Sacharin, Solbutamo

Abstract

Kinetic oxidation of Salbutamol by N-Chlorosaccharin, in aqueous Acetic acid medium, shows first-order dependence on [NCSA] and [H+], and fractional order on [Solbutamol]. The variation of [H+] and [Sacharin](reaction product) has a remarked effect on the rate of reaction(rate decreases). Activation parameters for the reaction have been evaluated from the Arrhenius plot by studying the reaction at different temperatures. The stoichiometry was found to be 1:1, and the products of oxidation were found to be 3-hydroxy methyl,4-hydroxy benzene carbaldehyde, Saccharin) and territory ammine as bi-products. The rate law has been derived on the basis of experimental Kinetic data and a plausible mechanism has been proposed.

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Author Biographies

Dr. Bashir Ahmad Dar, Govt. of J&K

Assistant Professor(Chemistry), Govt. Degree College (Boys) Sopore, India

Tariq Ahmad Khan

Department of Chemistry, APS University, Rewa,(M.P).

Shahid Shafi Shah

Department of Chemistry, APS University, Rewa,(M.P).

Fairooz Ahmad Khan

Department of Chemistry, Govt. Degree College Sopore, J&k(Kashmir).

R.K. Bamzae

Post-Graduate Department of chemistry university of Jammu, Jammu-180006 India.

M.U. Khan

Department of Chemistry, APS University, Rewa,(M.P).

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Published
2019-08-30
How to Cite
Dar, D. B. A., Khan, T. A., Shah, S. S., Khan, F. A., Bamzae, R., & Khan, M. (2019). Oxidative Cleavage of Solbutamol by N- Chloro Saccharin in Aqueous Acetic Acid Medium. To Chemistry Journal, 3, 41-55. Retrieved from http://purkh.com/index.php/tochem/article/view/412
Section
Research Articles