Antimicrobial Evaluation of Dichloro Chromene Isoxazoles and Isoxazoline Derivatives

  • Ashutosh K. Dash CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India
  • Nandan Sarkar
  • Nazar Hussain
  • Sabari Ghosal
  • Debaraj Mukherjee
Keywords: Benzopyran isoxazoles, Antibacterial assay, MIC, SAR×, MBC

Abstract

In the present study, the synthesized benzopyran isoxazolines and isoxazoles were evaluated for antibacterial activity by Agar well diffusion method against multi drug resistance (MDR) clinical isolates of five bacterial strains.i.e., Staphylococcus sp. (2413), Enterococcus sp. (2449), and Escherichia sp. (2461), Acinetobacter sp. (2457) and Serratia sp (2442). MIC (Minimum inhibitory concentration) and MBC (Minimum bactericidal concentration) of the potent derivatives were calculated and tabulated. A partial structure activity relationship (SAR) was done on the basis of microbial inhibition data. Compounds 3, 6, 8, 9, 11, 14 and 20 were the most promising antibacterial molecule. Compound 3, the precursor of isoxazole / isoxazoline found to be most active antibacterial candidate as well as bactericidal too.

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Author Biographies

Ashutosh K. Dash, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India

Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India

Nandan Sarkar

Centre for Plant and Environmental Biotechnology, Amity Institute of Biotechnology, AUUP, Noida- 201303, India

Nazar Hussain

academy of Scientific and Innovative Research, Jammu, 18000, CSIR-India

Sabari Ghosal

Centre for Plant and Environmental Biotechnology, Amity Institute of Biotechnology, AUUP, Noida- 201303, India

Debaraj Mukherjee

Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India

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Published
2019-08-30
How to Cite
K. Dash, A., Sarkar, N., Hussain, N., Ghosal, S., & Mukherjee, D. (2019). Antimicrobial Evaluation of Dichloro Chromene Isoxazoles and Isoxazoline Derivatives. To Chemistry Journal, 3, 56-67. Retrieved from http://purkh.com/index.php/tochem/article/view/413
Section
Research Articles