Monte Carlo Based Dose Assessment for 90Y Radioembolization, A Comparison between 99mtc-MAA SPECT/CT and 90Y-Microspheres PET

  • Sjoerd Rijnsdorp Catharina Hospital, Netherlands
  • Daniela Oprea-Lager VU University Medical Center, Netherlands
  • Jan de-Vries VU University Medical Center, Netherlands
  • Arthur van-Lingen VU University Medical Center, Netherlands
Keywords: Hepatocellular Carcinoma, Radioembolization, Yttrium-90 Microspheres, Technetium-99m Macroaggregated Albumin, Single Photon Emission Computed Tomography, Positron Emission Tomography

Abstract

The aim of this research was to assess the agreement between the distribution of technetium-99m macroaggregated albumin (MAA) and yttrium-90 microspheres in radioembolization of the liver, as well as the correspondence between the desired radiation dose and the true radiation dose in the target area.

Author Biographies

Sjoerd Rijnsdorp, Catharina Hospital, Netherlands

Department of Medical Physics, Catharina Hospital, Netherlands

Daniela Oprea-Lager, VU University Medical Center, Netherlands

Department of Radiology & Nuclear Medicine, VU University Medical Center, Netherlands

Jan de-Vries, VU University Medical Center, Netherlands

Department of Radiology & Nuclear Medicine, VU University Medical Center, Netherlands

Arthur van-Lingen, VU University Medical Center, Netherlands

Department of Radiology & Nuclear Medicine, VU University Medical Center, Netherlands

References

Global Burden of Disease Cancer Collaboration. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study. JAMA Oncol. 2017;3(4):524–548. doi: 10.1001/jamaoncol.2016.5688.

Schlachterman, A, Craft Jr, WW, Hilgenfeldt, E, Mitra, A, Cabrera, R. Current and future treatments for hepatocellular carcinoma. World J Gastroenterol. 2015;21(28):8478-8491. doi: 10.3748/wjg.v21.i28.8478.

Simon, N, Feitelberg, S. Scanning brehmsstrahlung of Yttrium-90 microspheres injected intra-arterially. Radiology. 1967 Apr;88(4):719-24. doi: 10.1148/88.4.719.

Houle, S, Yip, TK, Shepherd, FA, et al. Hepatocellular carcinoma: pilot trial of treatment with Y-90 microspheres. Radiology. 1989 Sep;172(3):857-860. doi: 10.1148/radiology.172.3.2549567.

Blanchard, RJ, Morrow, IM, Sutherland, JB. Treatment of liver tumors with yttrium-90 microspheres alone; Can Assoc Radiol J. 1989 Aug;40(4):206-210

Herba, MJ, Illescas, FF, Thirlwell, MP, et al. Hepatic malignancies: improved treatment with intraarterial Y-90; Radiology. 1988 Nov;169(2):311-314 doi: 10.1148/radiology.169.2.3174978.

Lau, WY, Leung, WT, Ho, S, et al. Treatment of inoperable hepatocellular carcinoma with intrahepatic arterial yttrium-90 microspheres: a phase I and II study. Br J Cancer. 1994;70(5):994-999.

ENSDF Decay Data in the MIRD (Medical Internal Radiation Dose) Format for 90Y

https://www.orau.org/ptp/PTP%20Library/library/DOE/bnl/nuclidedata/MIRY90.htm Accessed 10 november, 2017

Nickles, RJ, Roberts, AD, Nye, JA, et al. Assaying and PET imaging of yttrium-90: 1>34ppm>0. IEEE Symposium Conference Record Nuclear Science 2004., Rome, 2004, pp. 3412-3414 vol. 6. doi: 10.1109/NSSMIC.2004.1466619.

Lhommel, R, van Elmbt, L, Goffette, P, et al. Feasibility of 90Y TOF PET-based dosimetry in liver metastasis therapy using SIR-Spheres. Eur J Nucl Med Mol Imaging. 2010;37:1654–1662 doi: 10.1007/s00259-010-1470-9.

Gates, VL, Esmail, AA, Marshall, K, Spies, S, Salem, R. Internal pair production of 90Y permits hepatic localization of microspheres using routine PET: proof of concept; J Nucl Med. 2011 Jan;52(1):72-76. doi: 10.2967/jnumed.110.080986.

Elschot, M, Vermolen, BJ, Lam, MGEH, et al. Quantitative Comparison of PET and Bremsstrahlung SPECT for Imaging the In Vivo Yttrium-90 Microsphere Distribution after Liver Radioembolization. Villa E, ed. PLoS ONE. 2013;8(2):e55742. doi: 10.1371/journal.pone.0055742.

Garin, E, Rolland, Y, Pracht, M, et al. High impact of macroaggregated albumin‐based tumour dose on response and overall survival in hepatocellular carcinoma patients treated with 90Y‐loaded glass microsphere radioembolization. Liver Int. 2017;37(1):101-110. doi: 10.1111/liv.13220.

Srinivas, SM, Natarajan, N, Kuroiwa, J, et al. Determination of radiation absorbed dose to primary liver tumors and normal liver tissue using post-radioembolization 90Y PET. Front Oncol. 2014;4:255. doi: 10.3389/fonc.2014.00255.

Kao, Y-H, Steinberg, JD, Tay, Y-S, et al. Post-radioembolization yttrium-90 PET/CT - part 2: dose-response and tumor predictive dosimetry for resin microspheres. EJNMMI Research. 2013;3:57. doi: 10.1186/2191-219X-3-57.

Garin, E, Rolland, Y, Lenoir, L, et al. Utility of quantitative 99mTc-MAA SPECT/CT for 90yttrium-labelled microsphere treatment planning: calculating vascularized hepatic volume and dosimetric approach. Int J Mol Imaging. 2011;2011:398051. doi: 10.1155/2011/398051.

Matej, S, Lewitt, RM. Practical considerations for 3-D image reconstruction using spherically symmetric volume elements. IEEE Trans Med Imaging. 1996;15(1):68-78. doi: 10.1109/42.481442.

Boellaard, R, Delgado-Bolton, R, Oyen, WJG, et al. FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging. 2015;42:328-354. doi: 10.1007/s00259-014-2961-x.

Jan, S, Santin, G, Strul, D, et al. GATE - Geant4 Application for Tomographic Emission: a simulation toolkit for PET and SPECT. Phys Med Biol. 2004;49(19):4543-4561.

Schneider, W, Bortfeld, T, Schlegel, W, et al. Correlation between CT numbers and tissue parameters needed for Monte Carlo simulations of clinical dose distributions; Phys Med Biol. 2000 Feb;45(2):459-478.

Devaney, JJ. Beta spectra of 90Sr and 90Y. 1985;LA--10467-MS. United States

Garin, E, Rolland, Y, Laffont, S, Edeline, J. Clinical impact of 99mTc-MAA SPECT/CT-based dosimetry in the radioembolization of liver malignancies with 90Y-loaded microspheres. Eur J Nucl Med Mol Imaging. 2016;43:559-575. doi: 10.1007/s00259-015-3157-8.

Kao, YH, Hock Tan, AE, Burgmans, MC, et al. Image-guided personalized predictive dosimetry by artery-specific SPECT/CT partition modeling for safe and effective 90Y radioembolization; J Nucl Med. 2012 Apr;53(4):559-566. doi: 10.2967/jnumed.111.097469

Strigari, L, Sciuto, R, Rea, S, et al. Efficacy and toxicity related to treatment of hepatocellular carcinoma with 90Y-SIR spheres: radiobiologic considerations; J Nucl Med. 2010 Sep;51(9):1377-1385. doi: 10.2967/jnumed.110.075861

Song, YS, Paeng, JC, Kim, H-C, et al. PET/CT-Based Dosimetry in 90Y-Microsphere Selective Internal Radiation Therapy: Single Cohort Comparison With Pretreatment Planning on 99mTc-MAA Imaging and Correlation With Treatment Efficacy. Zakko. S, ed. Medicine. 2015;94(23):e945. doi: 10.1097/MD.0000000000000945.

Knesaurek, K, Machac, J, Muzinic, M, et al.; Quantitative comparison of yttrium-90 (90Y)-microspheres and technetium-99m (99mTc)-macroaggregated albumin SPECT images for planning 90Y therapy of liver cancer; Technol Cancer Res Treat. 2010 Jun;9(3):253-262. doi: 10.1177/153303461000900304

Wondergem, M, Smits, ML, Elschot, M, et al.; 99mTc-macroaggregated albumin poorly predicts the intrahepatic distribution of 90Y resin microspheres in hepatic radioembolization; J Nucl Med. 2013 Aug;54(8):1294-1301. doi: 10.2967/jnumed.112.117614

Gnesin, S, Canetti, L, Adib, S, et al. Partition model-based 99mTc-MAA SPECT/CT predictive dosimetry compared with 90Y TOF PET/CT posttreatment dosimetry in radioembolization of hepatocellular carcinoma: a quantitative agreement comparison; J Nucl Med. 2016 Nov;57(11):1672-1678; doi: 10.2967/jnumed.116.173104

Rhee, S, Kim, S, Cho, J, et al. Semi-quantitative analysis of post-transarterial radioembolization 90Y microsphere positron emission tomography combined with computed tomography (PET/CT) images in advanced liver malignancy: comparison with 99mTc macroaggregated albumin (MAA) single photon emission computed tomography (SPECT). Nucl Med Mol Imaging. 2016;50(1):63-69. doi: 10.1007/s13139-015-0366-9.

Published
2018-08-29
Section
Research Articles