Synthesis, Crystal Structure and Antimicrobial Properties of 1-Diphenylmethylpiperazine-1,4-Diium Tetrachloridocuprate

  • Sonia Mokaddem
  • Hadda-Imene Ouzari
  • Nedra Korbi
  • Habib Boughzala IPEIN
Keywords: Crystal structure, DRX, copper, 1-diphenylmethylpiperazine, hybrid material, infrared spectroscopy, antimicrobial activity, RDA


New organic/inorganic hybrid (C17H22N2)[CuCl4] was elaborated and studied by single crystal X-ray diffraction. The compound crystallizes in the orthorhombic Pbca space group. The isolated [CuCl4]2- tetrahedra are slightly distorted building a 0-D anionic framework. The double protonation of the organic cation establish N—H···Cl interactions between organic and inorganic moieties leading to self-organized structure. Infrared, UV-Visible and photoluminescence studies were carried out. The in-vitro antibacterial and antifungal activity of the title salt against several microorganisms were studied. The purity of the material was controlled by Rietveld analysis based on structural investigations and X-ray powder diffraction.


Download data is not yet available.


Rao, C. N. R.; Chheetham, A. K; Thirumurugan, A. J. Phys. Condens. Mater. 2008, 20, 1-23.

Fang, Q. R.; Zhu, G. S.; Jin, Z.; Xue, M. ; Wei, X. ; Wang D. J.; Qiu S. L. Angew. Chem. Inter. Edn. 2006, 45, 6126-6130.

Wang, S.; Hou, Y.; Wang, E.; Li, Y.; Xu, L.; Peng, J.; Liua S.; Hua, C. New J. Chem. 2003, 27, 1144-1147.

Gust, R.; Beck, W.; Jaouen, G.; Schoenenberger, H. Coord. Chem. Rev. 2009, 253, 2760-2779.

Gust, R.; Beck, W.; Jaouen, G.; Schoenenberger, H. Coord. Chem. Rev. 2009, 253, 2742-2759.

Boulikas, T.; Pantos, A.; Bellis E.; Christofis, P. Cancer Ther. 2007, 5, 537-537.

Zutphen, V.; Reedijk, S. J. Coord. Chem. Rev. 2005, 249, 2845-2845.

Solomon, E. I.; Hepper, D. E.; Johnston, E. M.; Ginsbach, J. W.; Cirera J.; Qayyum, M.; Kieber-Emmons, M. T.; Kjaergaard, C. H.; Hadt, R. G.; Tian, L. Bioinorganic Enzymology. 2014, 114, 3659-3853.

Creaven, B.; Duff, B.; Egan, D.;Kavanagh, K.; Rosair, G.; Thangella, V.; Walsh, M. Inorg. Chim. Acta. 2010, 363, 4048–4058.

Hammar, P.; Dender, D.; Reich, D. J. Appl. Phys. 1997, 81, 4615-4617.

Shapiro, A.; Landee, C.; Turnbull, M.; Jornet, J.; Deumal, M.; Novoa, J.; Robb, M.; Lewis, W. J. Am. Chem. Soc. 2007, 129, 952-959.

Dammak, T., Boughzala, H.; Mlayah, A.; Abid, Y. J. Lumin. 2016, 173, 213–217.

Harms, K; Wocadlo, S. XCAD4. Program for Processing CAD-4 Diffractometer Data. (1995), University of Marburg, Germany.

North, A.C.T.; Phillips, D.C.; Mathews, F. S. Acta Cryst. A 1968, 24,351–359.

Sheldrick, G. M. Acta Cryst. A 2008, 64, 112‐122.

Sheldrick, G. M. Acta Cryst. C 2015, 71, 3–8.

Brandenburg, K. DIAMOND. 3.1, Crystal Impact GbR, Bonn, Germany, 2008.

Lehrer, RI. ; Rosenman, M., ; Harwig, SS., Jackson, R., Eisenhauer, P. Ultrasensitive assays for endogenous antimicrobial polypeptides. J immunological methods. (1991),137,167-73.

Bhattacharya, R.; Chanda, S.; Bocelli, G.; Cantoni, A.; Ghosh, A. J. Chem. Cryst. 2004, 34, 393-400.

Yuan, B. L.; Lan, H.C. ; Chen, Y.P. ; Li, Y.B. Acta Cryst. E 2004, 60, 617–619.

Walsh, S. E. ; Maillard, J. Y. ; Russell, A. D. ; Catrenich, C. E. ; Charbonneau, D. L. ; Bartolo, R. G. J Hospital Infection, (2003), 55, , 98-107.

CaChe: work system Pro Version, Fujitsu Limited.2000–2006 Oxford Molecular.

Coelho, A. A. TOPAS, version 4.2 (Computer Software), Coelho Software, 2009.

Origin 9.0. OriginLab Corporation One Roundhouse Plaza Northampton, MA 01060. USA

C.Tamuly, N. Barooah, A. S. Batsanov,R. Kataky et J. B. Baruah, Inorg. Chem. Comm., 8, (2005), 689–691

T. Dammak, H. Boughzala, A. Mlayah et Y. Abid, J. of Luminescence, 173, (2016), 213-217.

R. Fu, S. Hu, X. Wu, Cryst. Eng. Comm. 13, (2011), 6334–6336.

How to Cite
Mokaddem, S., Ouzari, H.-I., Korbi, N., & Boughzala, H. (2018). Synthesis, Crystal Structure and Antimicrobial Properties of 1-Diphenylmethylpiperazine-1,4-Diium Tetrachloridocuprate. To Chemistry Journal, 1(3), 300-312. Retrieved from
Research Articles