Influence of Particle Size on the Anticonvulsant Activity of Propoxazepam



Propoxazepam, Particle Sizes, Molecular Structure, Anticonvulsant Activity


The granulometric composition of new analgesic substance (7-bromo-5-(o-chlorophenyl)-3-propoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one) was characterized by methods of crystals microscopy and lazer diffraction,. The single polymorphic phase demonstrated by differential scanning calorimetry, X-ray diffraction analysis, Raman and IR-spectroscopy. On the base of the anticonvulsive effect on mice in compare to coarse сcrystalline sample the conclusion about the higher pharmacological effect for the disperse sample had been demonstrated.


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How to Cite

Reder, A., Larionov, V., Golovenko, N., & Andronati, S. (2019). Influence of Particle Size on the Anticonvulsant Activity of Propoxazepam. To Chemistry Journal, 2, 132-141. Retrieved from



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