Novel 3,5-Diaryl-4,5-dihydro-1H-pyrazole Derivatives: Synthesis, Antioxidant, Antimicrobial and Docking Study Against Glucosamine-6-phosphate Synthase

Authors

  • Ahmed Mutanabbi Abdula Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq
  • Ban Hasan Taresh Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq
  • Mustafa Taha Mohammed Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq
  • Salah M Baqer Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq
  • Mohammed A. AL-Jaleel Khalil Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq
  • Ali Hameed Rasheed Medical Technical Institute / Mansour, Middle Technical University, Baghdad, Iraq

Keywords:

docking study, antioxidant, antimicrobial, Pyrazoline

Abstract

In our attempt to exploring a new class of antimicrobial and antioxidant agents, novel 4,5-dihydro-1H-pyrazole derivatives were synthesized and characterized by some spectroscopic methods such as FTIR, 1HNMR, and GCMS. The antioxidant property for all the synthesized derivatives against DPPH radical was examined using TLC autographic assay then the scavenging activity was determined using the spectroscopic method. The antimicrobial study against several bacterial species (gram +ve and gram –ve) as well as candida Albicans of the potent hits, which exhibited the highest scavenging activity, was determined using a good diffusion method. The docking approach was used to explain the binding affinity of the lead hit four inside the binding site of Glucosamine-6-phosphate Synthase, the target enzyme for the antimicrobial agents.

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Published

2020-08-15

How to Cite

Ahmed Mutanabbi Abdula, Ban Hasan Taresh, Mustafa Taha Mohammed, Salah M Baqer, Mohammed A. AL-Jaleel Khalil, & Ali Hameed Rasheed. (2020). Novel 3,5-Diaryl-4,5-dihydro-1H-pyrazole Derivatives: Synthesis, Antioxidant, Antimicrobial and Docking Study Against Glucosamine-6-phosphate Synthase. To Chemistry Journal, 6, 175-183. Retrieved from https://purkh.com/index.php/tochem/article/view/709

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Research Articles