Research Progress of Common Organic Guanidine Antibacterial Agents


  • Hua Li School of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China
  • Yingping Qi Zhengzhou museum, Zhengzhou China 450000
  • Yongfeng Shen Zhengzhou museum, Zhengzhou China 450000
  • Hua Li Zhengzhou museum, Zhengzhou China 450000


Organic guanidine, alkyl guanidine, aryl guanidine, polymerized guanidine, physical and chemical properties, application, preparation method, germicidal mechanism; germicidal efficacy


Aim: The aim of this study is to investigate the antimicrobial properties of organic guanidine because of their strong alkalinity, high stability, low toxicity and good biological activity. Methods: By referring to the relevant domestic and foreign literature, the physical and chemical properties, uses, preparation methods, germicidal efficacy and germicidal mechanism of guanidine compounds commonly used in alkyl guanidine, aryl guanidine, and polymerized guanidine with antibacterial properties were briefly analyzed and summarized. Result: It has been found that dodecylguanidine acetate in long-chain alkyl monoguanidine, iminoctadine in long-chain alkyl biguanide, chlorhexidine in aryl guanidine, polyhexamethylene biguanide hydrochloride(PHMB)
and polyhexamethylene guanidine hydrochloride(PHMG) in polymerized guanidine all had killing or inhibiting effects on bacteria, fungi and viruses. Conclusion: Guanidine compounds with broad-spectrum and high-efficiency bactericidal effect can not only be used as antibacterial agents alone, but also can be introduced into polymers to prepare materials with antibacterial properties, and the development prospect of organic guanidine antibacterial coatings is prospected.


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How to Cite

Hua Li, Yingping Qi, Yongfeng Shen, & Hua Li. (2020). Research Progress of Common Organic Guanidine Antibacterial Agents. To Chemistry Journal, 6, 163-174. Retrieved from



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