Research Progress of Common Organic Guanidine Antibacterial Agents

Authors

  • Hua Li School of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China
  • Yingping Qi Zhengzhou museum, Zhengzhou China 450000
  • Yongfeng Shen Zhengzhou museum, Zhengzhou China 450000
  • Hua Li Zhengzhou museum, Zhengzhou China 450000

Keywords:

Organic guanidine, alkyl guanidine, aryl guanidine, polymerized guanidine, physical and chemical properties, application, preparation method, germicidal mechanism; germicidal efficacy

Abstract

Aim: The aim of this study is to investigate the antimicrobial properties of organic guanidine because of their strong alkalinity, high stability, low toxicity and good biological activity. Methods: By referring to the relevant domestic and foreign literature, the physical and chemical properties, uses, preparation methods, germicidal efficacy and germicidal mechanism of guanidine compounds commonly used in alkyl guanidine, aryl guanidine, and polymerized guanidine with antibacterial properties were briefly analyzed and summarized. Result: It has been found that dodecylguanidine acetate in long-chain alkyl monoguanidine, iminoctadine in long-chain alkyl biguanide, chlorhexidine in aryl guanidine, polyhexamethylene biguanide hydrochloride(PHMB)
and polyhexamethylene guanidine hydrochloride(PHMG) in polymerized guanidine all had killing or inhibiting effects on bacteria, fungi and viruses. Conclusion: Guanidine compounds with broad-spectrum and high-efficiency bactericidal effect can not only be used as antibacterial agents alone, but also can be introduced into polymers to prepare materials with antibacterial properties, and the development prospect of organic guanidine antibacterial coatings is prospected.

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References

Zhan YZ, Zhao X. Research advances in organic guanidine antimicrobial. Melliand China. 2009;37(5):47-52. 2. Li Y, Li FG. Synthesis and application of polyhexamethylene biguanide hydrochloride. Fine Chem Industrial

Raw Materials Intermediates. 2011;13(2): 27-29. 3. Huang CH, Yu B. Novel bactericide long-chain alkyl guanidine. Fine Chem. 2002;19(12):51-53. 4. Gao HX, Lu RH, Wang HQ. Progress in study of guanidines. Chin J Organic Chem. 2011;21(7):485-492. 5. Horst B, Georg R, Alfred S. Guanidine fungicides. DE,3606294,1986-10-09. 6. Resnick Bruce M. Fungicidal process using 1-(alkylacyl) guanidines. US,DE3060827,1982-10-28. 7. Huang CH, Yu B. A novel bactericide--long chain alkyl guanidine. Industrial Water Treatment. 2002;22(7):9-11. 8. Sun CY, Guo XF, Ma N et al. Preparation of dodine. Fine Chem.1998;15(6):9-11. 9. Akashi H, Inoue T. Preparation of sparingly water soluble salts of dodecyl guanidine as antifouling agents

against marine organisms. Jpn, JP0225945,1998. 10. Song YB, Li QX, Li YL, et al. Synthesis and properties of dodecylguanidine hydrochloride. Fine Chem. 2013;30(1):28-31. 11. Tashiro N. The effectiveness of simultaneous application of benzimidazoles and iminoctadine triacetate on

the control green mold orchard of very early ripening Satsuma. Jpn J Phytopathology. 2008;74(4):297-303. 12. Capell T, Campos JL, Tiburcio AF. Antisenescence properties of guazatine in osmotically stressed oat leaves. Phytochemistry. 1993;32(4):785-788.

Yang YP, Li AL. Advances in the study of botanical fungicides. J Agricultural Sci Technol. 2006;8(1):49-53. 14. Ascherio A, Chen HL, Weisskopf MG et al. Pesticide exposure and risk for Parkinson’s disease. Annals

Neurol. 2006,60(2)197-203. 15. Zou QH, Yu ST, Liu FT, et al. Synthesis and biological activity of iminoctadine bactericide and its two

intermediates. Chem Research Application. 2003;15(6):865-867. 16. Lin L. Chlorhexidine skin prep preparation and study on its efficacy and safety. Shanghai: School of life

science and technology, Shanghai Jiao Tong University. 2010:1-26. 17. Tao XS, Zhang YT. The clinical observation of one minute hand-washing with chlorhexidine acetate and

alcohol and skin disinfection with pyrrolidone iodine . Chin J Practical Gynecol Obstetrics. 1992;8(1):33-34. 18. Boyce JM, Pittet D. Guideline for hand hygiene in health-care settings: Recommendations of the healthcare

infection control practices advisory committee and the hicpac/shea/apic/idsa hand hygiene task force. Am

J Infection Control. 2002;30(8):s1-s46. 19. Mangram AJ, Horan TC, Pearson ML, et al. Guideline for Prevention of Surgical Site. Am J Infection

Control. 1999;27(2)97-131. 20. Pratt RJ, Pellowe C, Loveday HP, et al. The epic Project: Developing National Evidence-based Guidelines for

Preventing Healthcare associated Infections. J Hospital Infection. 2001;47(Supplement):s3-s4. 21. O'Grady NP, Alexander M, Dellinger EP, et al. Guideline for the Prevention of Intravascular

Catheter-Related Infections. Am J Infection Control. 2002;30(8):476-489. 22. Cui SY, Chen L. Guanidine disinfectants and their research progress. Chin J Disinfection. 2011;28(6):749-751. 23. Wang S, Tao YL, Chen DF, et al. The preparations, capabilities and application of guanidine disinfectants. Guangdong Chem Industry. 2009;36(19):58-61. 24. Ling PX, Huang XD, Yue WX, et al. Disinfecting tablet containing chlorhexidine acetate and preparing

process thereof. Chin, CN98110399.5, 2000-2-23. 25. Killoy WJ. Assessing the effectiveness of locally delivered chlorhexidine in the treatment of periodontitis. J

Am Dental Association. 1999;30(4):567-570. 26. Zeng PY, Zhang GF, Rao A, et al. Concentration dependent aggregation properties of chlorhexidine salts. International J Pharm. 2009;367(1-2):73-78. 27. Song CL, Zhou AX, Wang JL. Comparison of chlorhexidine synthesis process. Heilongjiang Medicine Pharm. 1987;16(6):421-424. 28. McLellan E, Townsend R, Parsons HK. Evaluation of ChloraPrep (2% chlorhexidine gluconate in 70%

isopropyl alcohol) for skin antisepsis in preparation for blood culture collection. J Infection. 2008;57(6):459-463. 29. Edmiston CE, Seabrook GR, Johnson CP, et al. Comparative of a new and innovative 2% chlorhexidine

gluconate-impregnated cloth with 4% chlorhexidine gluconate as topical antiseptic for preparation of the

skin prior to surgery. Am J Infection Control. 2007;35(2):89-96. 30. Zeng J, Guan XQ, Li YH. Application of Avagard surgical water free hand sanitizer before operation. Chin J

Nosocomiol. 2007;1 (7):789. 31. Liu JL. Clinical application of chlorhexidine acetate disinfectant . J Nursing Sci. 1989;4(3):130. 32. Wang CS, Sun BQ, Yu ZQ, et al. Study on the property of polyhexamethylene biguanide hydrochloride

disinfectant. Hebei Medical J. 2014;36(17): 2588-2590. 33. Messick CR, Pendland SL, Moshirfar M, et al. In vitro activity of polyhexamethylene biguanide (PHMB)

against fungal isolates associated with infective keratitis. J Antimicrobial Chemotherapy. 1999;44(2):297-298. 34. Wei PZ, Xun YY, Zeng P, et al. Study on the synthesis process of polyhexamethylene biguanide

hydrochloride. Fine Specialty Chemicals. 2018;26(10):35-37. 35. Yan H, Han JS, Lin X, et al. Properties, application and synthesis progress of polyhexamethylene biguanide

hydrochloride. Shandong Chem Industry. 2017;46(20):47-48. 36. Lan F, Luan AB, Yang WH. Synthesis and antibacterial activity of polyhexamethylene guanidine

hydrochloride. Guangdong Chem Industry. 2008;35(4):92-93. 37. Zhao GL, Gao ZH, Li JL. Determination of polyhexamethylene guanidine hydrochloride in disinfectant

samples by fluorimetry. J South Chin Normal University(Natural Sci Edition). 2009;54(4):65-68. 38. Yang LC. Research progress in synthesis and application of polyhexamethylene guanidine hydrochloride. Chemical Enterprise Management. 2019;32(19):104-106. 39. Zhang L, Yao GY, Teng HK. Advances in the research of organic guanidine fungicides for industrial water

treatment. Guangdong Chem Indus. 2013;40(15):95-96. 40. Liu Q. Study on synthesis and application of polyhexamethylene guanidine hydrochloride papermaking

bactericide. Paper Sci Technol. 2017;36(6):40-44.

Published

2020-08-15

How to Cite

Hua Li, Yingping Qi, Yongfeng Shen, & Hua Li. (2020). Research Progress of Common Organic Guanidine Antibacterial Agents. To Chemistry Journal, 6, 163-174. Retrieved from https://purkh.com/index.php/tochem/article/view/753

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Section

Research Articles