Studies of Complexation of Transition Metal Ions With Benazepril Drug in Aqueous Media: Thermodynamic Aspect

Authors

  • Shailendrasingh Thakur Milliya College, Beed, India
  • M. A. Sakhare Balbhim College, Beed, India
  • D. B. Jirekar Anandrao Dhonde, Kada. Dist. Beed, India
  • Ramesh Ware Milliya College, Beed, India
  • P. P. Ghumare Anandrao Dhonde, Kada. Dist. Beed, India

Keywords:

thermodynamic parameter, pH metry, Benazepril, transition metal ions, stability constant

Abstract

Stability constant of Benazepril hydrochloride drug with transition metal ions Fe3+, Co2+, Ni2+, Cu2+, Zn2+ and Cd2+ using a pH metric titration technique in 20%(v/v) ethanol-water mixture at three different temperatures 300K, 310K & 320K at an ionic strength of 0.1M NaClO4 were studied. The Calvin-Bjerrum method as adopted by Irving-Rossotti has been employed to determine metal-ligand stability, constant logK values. The trend in the formation constants for transition metal ions follows the order: Fe3+ > Cu2+ > Cd2+> Co2+ > Zn2+ > Ni2+. The thermodynamic parameters, such as Gibb’s free energy change (ΔG), entropy change (ΔS), and enthalpy change (ΔH) associated with the complexation reactions, were calculated.

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Author Biographies

Shailendrasingh Thakur, Milliya College, Beed, India

Department of Chemistry

M. A. Sakhare, Balbhim College, Beed, India

Department of Chemistry

D. B. Jirekar, Anandrao Dhonde, Kada. Dist. Beed, India

Department of Chemistry                                                                                                                            

Ramesh Ware, Milliya College, Beed, India

Department of Chemistry                                                          

P. P. Ghumare, Anandrao Dhonde, Kada. Dist. Beed, India

Department of Chemistry

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Published

2020-06-13

How to Cite

Shailendrasingh Thakur, M. A. Sakhare, D. B. Jirekar, Ramesh Ware, & P. P. Ghumare. (2020). Studies of Complexation of Transition Metal Ions With Benazepril Drug in Aqueous Media: Thermodynamic Aspect. To Chemistry Journal, 6, 73-78. Retrieved from https://purkh.com/index.php/tochem/article/view/767

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Research Articles