Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media

Authors

  • Ramesh Ware Milliya College, Beed. (India)
  • D. B. Jirekar Anandrao Dhonde College, Kada, Dist. Beed. (India)
  • P. P. Ghumare Anandrao Dhonde College, Kada, Dist. Beed. (India)
  • Shailendrasingh Thakur Milliya College, Beed. (India)

Keywords:

pH metry, Efavirenz, transition metal, alkaline earth metal, Stability Constant

Abstract

The stability constant of Efavirenz drug with alkaline earth metal ions Mg(II), Ca(II)  and transition metal ions Fe(III), Cu(II) were investigate using pH metric titration technique in 20%(v/v) ethanol-water mixture at 27 °C temperature and at an ionic strength of 0.1M NaClO4.{Metal to ligand ratio = 1:5 & 1:1}The method of Calvin and Bjerrum as adopted by Irving and Rossotti has been employed to determine proton ligand (pKa) and metal-ligand stability constants (log K) values. It is observed that alkaline earth metal & transition metal ion forms 1:1 and 1:2 complexes. The order of stability constants for these metal complexes was as:                                                        Fe3+ > Cu2+ > Mg2+ > Ca2+    

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Author Biographies

Ramesh Ware, Milliya College, Beed. (India)

Department of Chemistry

D. B. Jirekar, Anandrao Dhonde College, Kada, Dist. Beed. (India)

Department of Chemistry

P. P. Ghumare, Anandrao Dhonde College, Kada, Dist. Beed. (India)

Department of Chemistry

Shailendrasingh Thakur, Milliya College, Beed. (India)

Department of Chemistry 

References

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Ramesh Ware and Shailendrasingh Thakur, Journal of Global Resources, July 2019,Volume 5(02), 265-269

Ramesh Ware, P.P.Ghumare, D.B.Jirekar, Shailendrasingh Thakur, RESEARCH JOURNEY International Multidisciplinary E-Research Journal, October 2019, Special Issue 199, 64-70

Shailendrasingh Thakur, H.U.Joshi, M.A. Sakhare, Ramesh Ware, RESEARCH JOURNEY International Multidisciplinary E-Research Journal, October 2019, Special Issue 199, 71-77.

Rajpal Jadhav, Ramesh Ware, Shailendrasingh Thakur, Journal of Research and Development, Jan.2020, Special Issue 02, Volume 10, 40-42.

Published

2020-06-13

How to Cite

Ramesh Ware, D. B. Jirekar, P. P. Ghumare, & Shailendrasingh Thakur. (2020). Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media . To Chemistry Journal, 6, 69-72. Retrieved from https://purkh.com/index.php/tochem/article/view/769

Issue

Section

Research Articles