“Indole” a versatile nucleus in pharmaceutical field.

Authors

  • Babasaheb Zine Bhagwan Mahavidyalaya , Ashti. Dist. Beed-414203, MS. India
  • Shrikant Dhonde Bhagwan Mahavidyalaya , Ashti. Dist. Beed-414203, MS. India.
  • Mazahar Farooqui Maulana Azad college , Aurangabad- 431001, MS, India.

Keywords:

Indole, Isatin, Anticancer, Antiviral, Anticonvulsant

Abstract

The present review article is related with the method of preparation, importance and medicinal application of indole. The studies of heterocycles are an evergreen field in the branch of organic chemistry and always attract the attention of chemists working not only in the area of natural products but also in the synthetic chemistry. Moreover many useful drugs have emerged from the successful investigation carried out in this branch. The derivatives of indoles exhibits antibacterial, anticancer, antioxidants, anti-inflammatory, antidiabetic, antiviral, atniproliferative, antituberculosis, antispermetogenic activity, antipsychotic drugs etc.

Downloads

Download data is not yet available.

Author Biography

Mazahar Farooqui, Maulana Azad college , Aurangabad- 431001, MS, India.

Principal

References

Baeyer A., Knop C. A. Ber., 140, 1, 1866.

Baeyer A., Emmerling A. Ber., 2, 679, 1869.

Elze F. Chem. Ztg., 34, 814, 1910.

Cerighelli R. Compt. Rend., 179, 1193, 1924.

Hesse A., Zeitschel O. J. Prakt. Chem., 66, 481, 1924.

Soden H. V. J. Prakt. Chem., 69, 256, 1904.

Sack J. Pharm. Weekblad, 48, 307, 1911.

Porcher C. Compt. Rend., 147, 214, 1908.

Nencki M. Ber., 7, 1593, 1874.

Stockly F. J. Prakt. Chem., 24, 17, 1881.

Ernst C. Physiol. Chem., 16, 208, 1892.

Weissberger R. Ber., 43, 3520, 1910

Boes. J. Pharm. Ztg., 47, 131, 1902.

Flower R. J., Moncada S., Vane J.R. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, seventh ed. 695, 1985.

Misra U., Hitkari A., Saxena A.K., Gurtu S., Shanker K., Eur. J. Med. Chem. 31 629-634, 1996.

Andreani A. M., Rambaldi A., Locatelli G., Pifferi, Eur. J. Med. Chem. 29 903-906, 1994.

Ebeid M.Y., Lashine S.M., El-Ad S.M., Abou K.M.I., Zagazig, J. Pharm. Sci. 3 , 40-48, 1994.

Rani P.,Srivastava V.K., Kumar A. Eur. J. Med. Chem. 39, 449-452, 2004.

Dubey P.K., Venkateshwar Kumar T., Raddanna P., Anil Kumar K. Indian J. Chem. 45B, 2128-2132, 2006.

Agarwal R., Agarwal C., Singh C., Misra V.S., J. Chem. Soc. Pak. 6, 89, 1984.

Verma M., Tripathi M., Saxena A.K., Shanker K., Eur. J. Med. Chem. 29, 941-946, 1994.

Kumar A., Saxena A.K., Shanker K. Pharmazie 43, 45-46, 1998.

Inion H., De Vogelaer H., Descamps M., Bauthier J., Colot M., Richard J., Charlier R. Chem. Abstr. 88, 601, 1978.

Mohamed Radwan A. A., Ragab E. A., Sabry N. M., Shenaw Ely S. M., Bioorg. Med. Chem.,15, 3832-3841, 2007.

Zheng M.kF., Zheng M., Deng D.Y., Oils S., Luo X., Chen K., Liu H., Jiang H. Bioorg. Med. Chem. Lett. 17, 2414-2420, 2007.

Sharma P., Kumar A., Pandey P. Indian J. Chem. 45B, 2077-2082, 2006.

Panwar R.S., Verma H., Srivastava V.K., Kumar A. Ind.J. Chem., 2099-2104, 2006.

Bhusare S.R., Shinde A.B., Pawar R.P., Vibhute Y.B. Ind. J. Pharm. Sci. 3, 228-231, 2004.

Dandia A., Sehgal V., Singh P. Ind. J. Chem. 32 B, 1288-1291, 1993.

Holla B.S., Udupa K.V. J. Ind. Chem. Soc. 65 (7), 524, 1988.

Archna Rani P., Bajaj K., Chandra R., Kumar A., Arzneim.-Forsch./Drug Res. 301-306, 2003.

Archna Rani P., Srivastava V.K, Kumar A. Indian J. Pharm. Sci. 65 (4) 356-362, 2003.

Bajji A.C., Channabasavaraj K.P., Swamy K.M.K. Indian Drugs 31 (6), 269-272, 1994.

El-Gendy Adel A., Abdou Naida A., El-Taber Z.S., El-Banna Hosny A., Alexandria J. Pharm. Sci. 7, 99-103, 1997.

Kumar A., Saxena K.K., Gurtu S., Sinha J.N., Shanker K. Indian Drugs 24, 1-5, 1986.

Bru-Magniez N., Guenger T., Tenton J.M., (Laboratories UPSA. Fr.) U.S.U 5,480,983 (Cl. 536-27, 62; C07H19/167), 2 Jan 1996, FR Appl. 92/ 138, 8 Jan 1992; 30 pp. Cont-in- part of U.S. 5,229,505 (Eng.) Chem. Abstr. 124 (17) 1996.

Kuethe J.T., Wong A., Smitrovich C., Qu, J., Davies I.W., Hughes D.L. J. Org. Chem.,70, 2555-2567, 2005.

Van Zandt M.C., Jones M.L.,Gunn D.E., Geraci L.S., Jones J.H., Sawicki D.R., Sredy J., Jacot J.L., Dicioccio A.T., Petrova T., Mitschler A., Podjarny A.D. J. Med. Chem.,48, 3141–3152, 2005.

Li J.J., Gribble G.W., Baldwin J., Williams (Eds.) R.M. Heterocyclic Chemistry, 20, 73-181, 2000.

Glennon R.A. J. Med. Chem., 30, 1-12, 1987.

Hiari Y. M. A., Qaisi. A. M., Abadelah M. M., Voelter W., Monatshefte. Fur Chemie, 137, 243, 2006.

Tao Wanga, John F. Kadow, Zhongxing Zhang, Zhiwei Yin, Qi Gao, Dedong Wub, Dawn DiGiugno Parker, Zheng Yang, Lisa Zadjura, Brett A. Robinson, Yi-Fei Gong, Wade S. Blair, Pei-Yong Shi, Gregory Yamanaka, Pin-Fang Lin ,Nicholas A. Meanwell Bioorg. Med. Chem. Lett. 19, 5140-5145, 2009.

Hong B. C., Jiang Y., Chang Y., Lee S. J Chin Chem Soc., 53, 647, 2006.

Enein H. Y. A., Kruk I., Lichszteld K., Michalska T., Kiadna A., Marczynski S., Olgen S. Luminescence, 19, 1, 2004.

Hakan Kandemier, Kasey wood, Naresh Kumar, David Black. Tetrahedron. 69,2193-2198 ,2013.

Kalaskar G. P., Girisha, M., Purohit M. G., Thippeswamy B. S., Patil B. M. Indian J. Heterocycl. Chem.,16,325, 2007.

Joshi K.C., Pathak V.N & Chand P., Agric. Bioi.Chem 42(9), 1723, 1978 Chem.Abstr. 90.22729, 1979

Li Y. Y., Wu H. S., Tang L., Feng C. R., Yu H.Y., Yang, Y. S., Yang B. J Pharmacol Res, 56,335, 2007.

Abele E., Abele R., Dzenitis O., Lukevics E. Chem. Heterocycl. Compd., 39, 3, 2003.

Jing-Ping Liou, Chang-Ying Wu, Hsing-Pang Hsieh, Chi-Yen Chang, Chi-Ming Chen, Ching-Chuan Kuo, and Jang-Yang Chang J. Med. Chem., 50 (18), 4548-4552, 2007.

Ozlen Guzel, Nalan Terziog Lu, Gultaze Capan, and Aydi Salman ARKIVOC (xii) 98-110, 2006.

Konkel M. J.,Lagu B., Boteju L.W., Jimenez H., Noble S., Walker M.W., Koirnberg B. E., Gregory T., Pugsley T.A., Zoski K., Wise L.D.J. Med. Chem.,49,3757, 2006.

Neelakandan V. L., Prakasam T., Noorulla K.M. 2010.

Zine B., Jadhav S., Dixit P., Farooqui M., J. of Ultrachem., Vol. 13(2), 30-34, 2017.

Published

2020-08-15

How to Cite

Babasaheb Zine, Shrikant Dhonde, & Mazahar Farooqui. (2020). “Indole” a versatile nucleus in pharmaceutical field. To Chemistry Journal, 6, 144-151. Retrieved from https://purkh.com/index.php/tochem/article/view/783

Issue

Section

Research Articles